Latest Publications


Suchland RJ, Carrell SJ, Ramsey SA, Hybiske K, Debrine AM, Sanchez J, Celum C, Rockey DD. Genomic analysis of MSM rectal Chlamydia trachomatis isolates identifies predicted tissue-tropic lineages generated by intraspecies lateral gene transfer-mediated evolution. Infect Immun. 2022 Oct 10:e0026522. PMID: 36214558. Cover artwork

Maddy J, Staker BL, Subramanian S, Abendroth J, Edwards TE, Myler PJ, Hybiske K, Asojo OA. Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2022 Mar 1;78(Pt 3):135–142. PMCID: PMC8900733


Garvin L, Vande Voorde R, Dickinson M, Carrell S, Hybiske K, Rockey D. A broad-spectrum cloning vector that exists as both an integrated element and a free plasmid in Chlamydia trachomatis. PLoS One. 2021 Dec 16;16(12):e0261088. PMCID: PMC8675754

Khosropour CM, Dombrowski JC, Vojtech L, Patton DL, Campbell LA, Barbee LA, Franzi MC, Hybiske K. Rectal Chlamydia trachomatis Infection: A Narrative Review of the State of the Science and Research Priorities. Sex Transm Dis. 2021 Dec 1;48(12):e223–e227. PMCID: PMC8595876

Dimond ZE, Suchland RJ, Baid S, LaBrie SD, Soules KR, Stanley J, Carrell S, Kwong F, Wang Y, Rockey DD, Hybiske K, Hefty PS. Inter-species lateral gene transfer focused on the Chlamydia plasticity zone identifies loci associated with immediate cytotoxicity and inclusion stability. Mol Microbiol. 2021 Dec;116(6):1433–1448. PMCID: PMC9119408. Cover artwork

Plotnikoff KM, Donken R, Smith L, Cameron C, LaMontagne DS, Bettinger JA, Sadarangani M, Grennan T, Racey CS, Hybiske K, Naus M, Monteiro A, Ogilvie GS. Priorities for sexually transmitted infection vaccine research and development: Results from a survey of global leaders and representatives. Vaccine X. 2021 Aug;8:100107. PMCID: PMC8356130


Waagmeester A, Stupp G, Burgstaller-Muehlbacher S, Good BM, Griffith M, Griffith OL, Hanspers K, Hermjakob H, Hudson TS, Hybiske K, Keating SM, Manske M, Mayers M, Mietchen D, Mitraka E, Pico AR, Putman T, Riutta A, Queralt-Rosinach N, Schriml LM, Shafee T, Slenter D, Stephan R, Thornton K, Tsueng G, Tu R, Ul-Hasan S, Willighagen E, Wu C, Su AI. Wikidata as a knowledge graph for the life sciences. Elife. 2020 Mar 17;9:e52614. PMCID: PMC7077981

Barrett KF, Dranow DM, Phan IQ, Michaels SA, Shaheen S, Navaluna ED, Craig JK, Tillery LM, Choi R, Edwards TE, Conrady DG, Abendroth J, Horanyi PS, Lorimer DD, Van Voorhis WC, Zhang Z, Barrett LK, Subramanian S, Staker B, Fan E, Myler PJ, Soge OO, Hybiske K, Ojo KK. Structures of glyceraldehyde 3-phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis. Protein Sci. 2020 Mar;29(3):768–778. PMCID: PMC7020975


Wang Y, LaBrie SD, Carrell SJ, Suchland RJ, Dimond ZE, Kwong F, Rockey DD, Hefty PS, Hybiske K. Development of Transposon Mutagenesis for Chlamydia muridarum. J Bacteriol. 2019 Dec 1;201(23):JB.00366–19. PMCID: PMC6832062

Suchland RJ, Carrell SJ, Wang Y, Hybiske K, Kim DB, Dimond ZE, Hefty PS, Rockey DD. Chromosomal Recombination Targets in Chlamydia Interspecies Lateral Gene Transfer. J Bacteriol. 2019 Dec 1;201(23):JB.00365–19. PMCID: PMC6832074

Khosropour CM, Soge OO, Suchland R, Leipertz G, Unutzer A, Pascual R, Hybiske K, Barbee LA, Manhart LE, Dombrowski JC, Golden MR. Recurrent/Intermittent Vaginal and Rectal Chlamydial Infection Following Treatment: A Prospective Cohort Study Among Female Sexually Transmitted Disease Clinic Patients. J Infect Dis. 2019 Jul 2;220(3):476–483. PMCID: PMC6603978

Dickinson MS, Anderson LN, Webb-Robertson BJM, Hansen JR, Smith RD, Wright AT, Hybiske K. Proximity-dependent proteomics of the Chlamydia trachomatis inclusion membrane reveals functional interactions with endoplasmic reticulum exit sites. PLoS Pathog. 2019 Apr;15(4):e1007698. PMCID: PMC6464245

Zuck M, Hybiske K. The Chlamydia trachomatis Extrusion Exit Mechanism Is Regulated by Host Abscission Proteins. Microorganisms. 2019 May 25;7(5). Available from: PMCID: PMC6560402

Putman T, Hybiske K, Jow D, Afrasiabi C, Lelong S, Cano MA, Stupp GS, Waagmeester A, Good BM, Wu C, Su AI. ChlamBase: a curated model organism database for the Chlamydia research community. Database. 2019 Jan 1;2019:baz091. PMCID: PMC6580685


Wang X, Hybiske K, Stephens RS. Direct visualization of the expression and localization of chlamydial effector proteins within infected host cells. Pathog Dis. 2018 Mar 1;76(2):fty011. PMCID: PMC6251622


Wang X, Hybiske K, Stephens RS. Orchestration of the mammalian host cell glucose transporter proteins-1 and 3 by Chlamydia contributes to intracellular growth and infectivity. Pathog Dis. 2017 Nov 30;75(8):ftx108. PMCID: PMC6433302

McFarland AP, Luo S, Ahmed-Qadri F, Zuck M, Thayer EF, Goo YA, Hybiske K, Tong L, Woodward JJ. Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State. Immunity. 2017 Mar 21;46(3):433–445. PMCID: PMC5404390

Zuck M, Ellis T, Venida A, Hybiske K. Extrusions are phagocytosed and promote Chlamydia survival within macrophages. Cell Microbiol. 2017 Apr;19(4):e12683. PMID: 27739160

Sherrid AM, Hybiske K. Chlamydia trachomatis Cellular Exit Alters Interactions with Host Dendritic Cells. Infect Immun. 2017 May;85(5):e00046–17. PMCID: PMC5400845

Recent Reviews

Khosropour CM, Dombrowski JC, Vojtech L, Patton DL, Campbell LA, Barbee LA, Franzi MC, Hybiske K. Rectal Chlamydia trachomatis Infection: A Narrative Review of the State of the Science and Research Priorities. Sex Transm Dis. 2021 Dec 1;48(12):e223–e227. PMCID: PMC8595876

Selected older publications

Zuck M, Sherrid A, Suchland R, Ellis T, Hybiske K. Conservation of extrusion as an exit mechanism for Chlamydia. Pathog Dis. 2016 Oct;74(7):ftw093. PMCID: PMC5985487

Hybiske K, Stephens RS. Exit strategies of intracellular pathogens. Nat Rev Microbiol. 2008 Feb;6(2):99–110. PMID: 18197167

Hybiske K, Stephens RS. Mechanisms of Chlamydia trachomatis entry into nonphagocytic cells. Infect Immun. 2007 Aug;75(8):3925–3934. PMCID: PMC1952008

Hybiske K, Stephens RS. Mechanisms of host cell exit by the intracellular bacterium Chlamydia. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11430–11435. PMCID: PMC2040915